Qwo for the treatment of Cellulite

What is QWO?

There are a multitude of ways women have tried to reduce their cellulite. QWO is the first and only FDA-approved injectable for the treatment of moderate to severe cellulite in the buttocks of adult women. QWO (pronounced kwhoa) contains two types of collagen-degrading enzymes that eat away at the fibrous bands (or fibrous septae) connecting skin to muscle, gradually dissolving the tethers and allowing the skin to float up and smooth out.

How does QWO work?

Women develop cellulite due to the connective bands attaching the skin to the structural tissues beneath. Fat is trapped inside the pockets between the bands, and it pushes up against the surface skin, creating the signature cottage cheese appearance of cellulite.

QWO works in three ways to improve the appearance of cellulite:
• It releases some of those fibrous bands
• It redistributes fat cells when those bands are broken
• It stimulates the production of new amounts of collagen

What is cellulite and what causes it?

Cellulite is a localized alteration in the contour of the skin that has been reported in approximately 90% of adult women of all races and ethnicities.

There are many misconceptions about cellulite. People think it is tied to fat, and that changes in diet and exercise could remove their cellulite. That’s not the case. Losing a lot of fat will lessen the appearance of cellulite somewhat, but it won’t make it go away. That’s why you’ve probably noticed, and been surprised to see, skinny women with cellulite.

That’s because fat isn’t the problem: the structural makeup of women’s skin is the cause. Women have connective tissue bands under their skin that are like vertical bars, trapping pockets of fat between them. The fat trapped by these tight bands pushes upward against the skin, creating lumps on the surface next to depressions where the connective tissue is separating the fat beneath. Yes, it’s the orange peel look of cellulite. And it only gets worse as we age and our skin thins.

Are fat and cellulite the same?

Fat is not cellulite and does not cause it, but fat cells getting bigger between fibrous bands under the skin can contribute to a bumpy appearance.

How many women have taken part in QWO studies?

QWO has been studied in more patients than any other FDA-approved injectable cellulite treatment, with over 1,800 women participating. In two pivotal phase 3 clinical studies of adult women with moderate to severe cellulite, 424 were treated with QWO and 419 received placebo.

How is QWO given?

Your provider begins by marking the dimpled areas on your buttocks that are to be injected. QWO is then injected with a very small needle. Injections do not need to be made to great depth. Topical numbing cream is not necessary. Because there is much more fat and far fewer nerves in the buttocks, these injections are not painful. Patients have told us they hurt less than Botox® injections, which also don’t necessitate the use of topical anesthetic cream when being delivered. QWO™ sessions are completely non-invasive and take just 10-20 minutes or so.

You should not receive QWO if you are allergic to any collagenase or the ingredients in QWO, or have an active infection in the treatment area.

How many treatments will I receive?

If your aesthetic specialist determines that QWO is right for you, she or he will decide on a treatment plan, including total number of treatments.

Each treatment visit may include up to 2 treatment areas. QWO injections will be given 21 days apart for 3 treatment visits.

How long do the injections take?

At each office visit, injections take as little as 10 minutes.

How long will it take to see my results from QWO?

At Kalia, we deliver QWO injections in three sessions separated by three weeks between each session. That adds up to a total of about 10 weeks. That’s about the time frame you can expect to see visible smoothing of the areas on your buttocks that were treated. It takes time for the enzyme reactions to break down more and more of the connective bands and free those connections to lessen the dimpled appearance of cellulite. This is a new treatment at Kalia, and there is variability between patients on their results and how soon they see them.

Are there any side effects?

QWO may cause serious side effects including allergic (hypersensitivity) reactions, including anaphylaxis, and injection site bruising. The most common side effects of QWO include: injection site bruising, pain, areas of hardness, itching, redness, discoloration, swelling and warmth in the treatment area. These are not all the possible side effects of QWO.

How much bruising can I expect after each treatment?

QWO may cause serious side effects: allergic (hypersensitivity) reactions, including anaphylaxis and injection site bruising.
In clinical trials, women required no post-treatment downtime. Most bruising lessened after each treatment and resolved in less than 21 days.

Qwo on News4

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